USA Major League Soccer Betting Odds

Major League Soccer is now one of the most-watched football leagues in the world, thanks to an increasing domestic interest in “soccer” and the fact that Lionel Messi, one of the greatest players of all time, plays for David Beckham’s Inter Miami.  

Though not as competitive as the top leagues in Europe, MLS is evolving, with new teams, top talents, and some of the best stadia in world football ahead of the World Cup, which will arrive Stateside in 2026.

Read on to learn how to bet on Major League Soccer this season at Betano Sportsbook, which includes the most popular markets and betting options. 

Major League Soccer (MLS) is one of the newest professional football leagues in the world. It was established in 1996 after the success of the 1994 FIFA World Cup in the United States.  

Unlike top European leagues, MLS doesn’t have a promotion or relegation system, and each team within the league is a franchise.   

Currently, 30 teams compete in MLS, 27 from the United States and three from Canada. They are split into two conferences – Eastern and Western – as shown below:  

Eastern Conference  

• Atlanta United  
• Charlotte FC  
• Chicago Fire  
• FC Cincinnati  
• Columbus Crew  
• DC United  
• Inter Miami  
• CF Montreal  
• Nashville SC  
• New England Revolution  
• New York City FC  
• New York Red Bulls  
• Orlando City SC  
• Philadelphia Union  
• Toronto FC  

Western Conference  

• Austin FC  
• Colorado Rapids  
• FC Dallas  
• Houston Dynamo FC  
• LA Galaxy  
• Los Angeles FC  
• Minnesota United  
• Portal Timbers  
• Real Salt Lake  
• San Diego FC  
• San Jose Earthquakes  
• Seattle Sounders  
• Sporting Kansas City  
• St Louis City SC  
• Vancouver Whitecaps FC  

Each MLS team plays two games against the other teams in their conference and six games against teams from the other conference. There’s an All-Star Game midway through the season, and a post-season knock-out tournament is contested to determine the winner.  

The MLS Cup Playoffs are competed by the top 18 teams, culminating in the MLS Cup odds in early December. Current champions LA Galaxy are the most successful team in MLS history, with six titles.  

The Supporters’ Shield is also awarded at the end of the MLS season to the team with the best regular-season record. Lionel Messi’s Inter Miami are the current holders of the Supporters’ Shield.   

If you’d like to watch MLS in the UK, sign up for an MLS pass via Apple TV to watch all the live action. 

Los Angeles Galaxy, the team made popular in the UK by David Beckham, are the most successful team in MLS history, with six MLS Cups and four Supporters’ Shields. Check out the table below, showing all teams with at least two MLS Cups to their name at the time of writing:  

The Best Players in MLS in 2025  

Lionel Messi mania in 2025 is just as pronounced as David Beckham mania was when the England legend joined LA Galaxy in 2007. The Argentine superstar is the most decorated player in MLS and is second only to Pele in terms of the greatest players ever played professionally in North America.  

Messi is joined at Inter Miami by several teammates from the irresistible Barcelona team from around ten years ago, including Sergio Busquets, Luis Suarez, and Jordi Alba. It has “getting the band back together vibes”, and it’s a formula that has worked for Inter Miami, propelling the team into a globally watched franchise and securing impressive results on the pitch.  

Outside of Miami, former Liverpool striker Christian Benteke has found form leading the line for DC United. He finished last season as the top scorer in MLS, scoring 23 goals for his team. Dejan Lovelic’s 21 goals propelled LA Galaxy to the title last season, and he’s another to watch this campaign, though he will turn out for Sporting Kansas City this term.  

One of the star MLS players across the last three seasons is Luciano Acosta, who regularly appears in the All-Star game. The Argentinian midfielder may not have any international caps to his name, but he has been one of the best players in the league since first arriving in the US in 2017. He has represented DC United and Cincinnati and will play for FC Dallas this season.  

If you want to bet on Messi, Suarez, and other top stars in MLS, here are some of your options at Betano:  

• Match betting: Bet on all MLS matches throughout the season, beginning with the curtain raiser on March 1st between Charlotte and Atlanta United. We also offer one-up and two-up early payout markets for MLS matches.  
• Over/under (totals): Rather than picking the winner of an MLS match, bet on the total number of goals you think will be scored, over or under 1.5, 2.5, or 3.5.  
• BTTS: You can include MLS matches in your both teams to score accumulator throughout the campaign. You will win your bet if both teams find the back of the net in an MLS fixture.  
• Draw no bet: Take the tie out of the equation and place a draw-no bet on any MLS fixture. Though it reduces your odds, it makes your selection more likely.  

MLS has come a long way since 1996 and is now a globally-watched football league. You can bet on all Major League Soccer matches in the 2024-25 season by creating an account at Betano. Register today by clicking the “Sign Up” button. Then, follow the prompts to create your account.  

Before depositing via the cashier, check out our promotions page to see if you can access a new customer offer or other MLS betting offers. Then, add funds and start betting on MLS this season.  

Please remember to gamble responsibly when betting on football, including MLS matches, at Betano. Visit our Safer Gambling Portal for advice and tools to help you bet within your means.